Post-Doctoral Position - Epigenetics & Innate Immune Training
Zoetis

Kalamazoo, Michigan

Posted in Pharmaceuticals
15 days ago


Job Info


Company: Zoetis

Title: Post-Doctoral Position - Epigenetics & Innate Immune Training

Location: Kalamazoo, Michigan, USA

The Zoetis Global Therapeutics Research group is seeking an innovative and highly motivated Post -Doctoral epigeneticist (Chromatin Immunoprecipitation 'ChIP' focus) to contribute towards discovery and development of novel therapies. The team works across various therapeutic areas and is geared to understanding the immunological basis of chronic inflammation, infectious/non-infectious disease and host-pathogen interactions in order to identify, evaluate and progress therapeutic targets and substrates for companion animals and livestock.

Responsibilities:

•Develop, adapt, and implement new epigenetic research techniques and ChIP protocols for ChIP-Seq and other related approaches

•Perform routine and complex, specialized, laboratory procedures including chromatin/methylated DNA isolation and ChIP-Seq for investigators

•Characterize altered immune cells relevant to disease targets and conduct epigenomic characterization

•Work closely with the Mechanistic Biology, Genetics/Bioinformatics, Mass Spec/PDMA/Bioanalytical teams to provide expert advice/service in ChIP-Seq-related experimental design and to implement quality controls to assure high scientific standards

Basic Qualifications:

Suitable candidates will have a PhD in Epigenetics or related biomedical/biology area with a focus on ChIP e.g. histone modifications and transcription factors immunoprecipitation assays. Have extensive experience with chromatin immunoprecipitation, and enthusiasm to learn ChiP-Seq data analysis/bioinformatics to address biological questions and disease-relevant investigative research. Have ability to work independently in research projects within area of specialization. They must also be a creative/independent thinker and with a track record of research in genomics/epigenomics and peer reviewed publications.

Desired Skill sets:

•In-depth knowledge of epigenetics and extensive hands-on experience in ChIP assay development and expertise with standard assay formats (e.g. chromatin isolation, fragmentation, agarose gel electrophoresis, immunoprecipitation, etc.).

•In-depth knowledge in DNA/RNA/protein isolation from tissue/cell-based assay systems

•Familiarity with total histone isolation, SDS-PAGE, histone modification assays, qPCR or RNASeq, and isolation of methylated DNA and downstream sequencing

•Broad knowledge in utility/application of epigenetics for either identification of therapeutic targets or identification and application for biomarkers in efficacy/safety studies.

•Familiarity with immunological concepts and techniques (in vivo, ex vivo and in vitro)

•Familiarity/interest in learning next-generation sequencing (Illumina Sequencing), ChIP-Seq data analysis (mapping, peak finding, motif analysis, gene ontology analysis, etc.)

Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.

Full time

Regular

Colleague

Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of "@zoetis.com". In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.



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