Bioanalytical LC-MS Senior Scientist
Zoetis

Job Info

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Zoetis Veterinary Medicine Research and Development (VMRD) seeks an enthusiastic colleague for a project representative role within our bioanalytical group supporting research and development of veterinary medicines in Kalamazoo, Michigan. The candidate will work closely with representatives supporting target animal safety, toxicology, pharmacokinetics, environmental, clinical, and regulatory sciences as part of multidisciplinary project teams, and may include both internal study support as well as outsourcing efforts. The candidate will work as part of a larger bioanalytical team to develop and validate quantitative LC-MS/MS bioanalytical methods, and perform bioanalysis in support of non-regulated (discovery, fit-for-purpose) and regulated (GLP) studies. Preference will be given to candidates with previous experience in large molecule bioanalysis, pharmacokinetics, drug metabolism, and/or outsourcing of bioanalytical methods. Experience developing analytical procedures for large molecule protein therapeutics using lowflow LC-MS/MS and multi-dimensional separation methods for the identification and quantification of proteins is highly desirable.

Responsibilities:

• Independent hands-on method development and validation of LC-MS/MS methods (SRM, PRM) to quantify veterinary therapeutics in complex matrices with emphasis on large molecule protein therapeutics. Preference will be given to candidates with sufficient experience to provide mentorship and guidance in the laboratory.

• Analytical subject matter expert and project team representative for VMRD Global Metabolism & Safety.

• Work with project teams, study directors, and regulatory affairs to support or conduct studies within agreed upon timelines.

• Prepare reports and present results to scientific teams and management.

• Participate/lead continuous improvement and innovation efforts within the VMRD Global Metabolism & Safety group.

Minimum Qualifications:

• Ph.D. (0 - 2 years of relevant experience), M.S. (with 5+ years of relevant experience), or B.S. (with 10+ years of relevant experience) in chemistry, biochemistry, or related field, with hands-on experience using mass spectrometry techniques to characterize and quantify large molecule therapeutics and/or biomarkers.

• Exhibits enthusiasm for analytical chemistry and has a high degree of attention to detail.

• Ability to work effectively as both an individual contributor and in a collaborative team setting.

• Track record of successfully troubleshooting issues that arise during bioanalytical assay development, qualification, validation, and sample analysis.

• Understanding of quality expectations and regulatory guidance around LC-MS therapeutic and/or biomarker assay development and validation.

• Demonstrated ability to develop, optimize, and validate LC-MS methods for quantitative analysis of analytes in biological matrices (serum, tissue, cell culture).

• Experience with the proper handling and storage of therapeutic and biomarker biological samples and associated critical reagents.

• Excellent written and oral communication skills.

Desired Skill Sets:

• Experience with quantitative protein analysis by mass spectrometry (multi-dimensional low-flow LC/MS, extraction or enrichment techniques (protein crash, SPE, immuno-affinity, for example).

• Experience with bottom-up and top-down proteomic workflows.

• Experience with in silico software tools that facilitate the development of large molecule LC/MS assays (ex: alignment tools, BLAST, Skyline, PeptideAtlas).

• Experience with the operation and maintenance of triple quadrupole mass spectrometers. Specifically SCIEX (Analyst Software) and Waters (MassLynx) platforms, or equivalent).

• Experience with the operation and maintenance of hybrid quadrupole-orbitrap mass spectrometers (Q-Exactive and Exploris series), or equivalent HRMS instrumentation.

• Experience with HPLC and UPLC systems is required. Experience with low-flow (nano or capilliary flow) UHPLC systems is highly desirable (Thermo UltiMate 3000 RSLCnano System, or equivalent).

• Experience with small molecule extraction techniques and basic/advanced large molecule extraction techniques for both biological fluid and tissue matrices. Experience with protein digestion and automated extraction instruments is highly desirable.

• Experience with laboratory automation for sample extraction workflows. Advanced knowledge of Hamilton Microlab STAR Liquid Handling System and programming (Venus software) is a plus.

• Familiarity with ligand binding assays and how to leverage critical reagents to develop a hybrid-LBA LCMS assay.

• Experience with LIMS and/or PK software, such as Watson and WinNonLin, is a plus.

• Experience working in a regulated laboratory (GLP), including writing SOPs, is a plus.

Full time

Regular

Colleague

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